Paul M Sondel Selected Research

Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)

3/2007	Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG-oligodeoxynucleotides.
6/2006	Tumoristatic effects of anti-CD40 mAb-activated macrophages involve nitric oxide and tumour necrosis factor-alpha.
1/2006	Synergistic activation of macrophages via CD40 and TLR9 results in T cell independent antitumor effects.

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Paul M Sondel Research Topics

Disease

100	Neoplasms (Cancer) 04/2024 - 09/2002
49	Neuroblastoma 04/2024 - 01/2004
23	Melanoma (Melanoma, Malignant) 12/2023 - 01/2005
7	Hypotension (Low Blood Pressure) 12/2022 - 03/2006
6	Hypersensitivity (Allergy) 12/2022 - 07/2006
6	Experimental Melanoma 01/2021 - 05/2005
6	Pain (Aches) 12/2018 - 07/2006
5	Neoplasm Metastasis (Metastasis) 12/2023 - 07/2004
5	Necrosis 01/2016 - 06/2006
4	Breast Neoplasms (Breast Cancer) 03/2024 - 08/2004
4	Fever (Fevers) 12/2022 - 01/2009
3	Residual Neoplasm 10/2019 - 07/2009
3	Capillary Leak Syndrome 01/2018 - 01/2009
3	Renal Cell Carcinoma (Grawitz Tumor) 05/2017 - 09/2002
2	Osteosarcoma (Osteogenic Sarcoma) 09/2022 - 01/2021
2	Squamous Cell Carcinoma of Head and Neck 01/2022 - 01/2021
2	Lymphoma (Lymphomas) 01/2021 - 02/2009
2	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 12/2019 - 01/2017
2	Hypoxia (Hypoxemia) 01/2017 - 11/2010
2	Lymphocytosis 12/2012 - 03/2006
2	Sarcoma (Soft Tissue Sarcoma) 08/2008 - 07/2006
2	Adenocarcinoma 08/2004 - 09/2002
1	Carcinogenesis 11/2023
1	Sudden Death 09/2022

Drug/Important Bio-Agent (IBA)

32	Interleukin-2 (IL2)IBA 04/2024 - 01/2004
29	Monoclonal AntibodiesIBA 04/2024 - 06/2003
21	lorukafusp alfaIBA 04/2024 - 01/2004
19	CytokinesIBA 12/2022 - 06/2003
15	dinutuximabIBA 01/2023 - 07/2006
14	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2023 - 01/2007
12	AntibodiesIBA 10/2022 - 07/2006
9	LigandsIBA 01/2023 - 12/2010
8	VaccinesIBA 07/2023 - 01/2010
7	Proteins (Proteins, Gene)FDA Link 01/2023 - 06/2003
7	Immune Checkpoint InhibitorsIBA 10/2022 - 01/2021
6	Interleukin-12 (IL 12)IBA 09/2022 - 09/2002
6	Isotretinoin (Accutane)FDA LinkGeneric 10/2019 - 09/2010
6	AntigensIBA 01/2016 - 01/2010
5	Radioisotopes (Radionuclides)IBA 12/2023 - 12/2007
5	OligodeoxyribonucleotidesIBA 07/2023 - 03/2007
5	Neoplasm Antigens (Tumor Antigens)IBA 01/2022 - 12/2008
5	Immunoglobulin G (IgG)IBA 01/2020 - 01/2016
4	Irinotecan (Camptosar)FDA LinkGeneric 01/2023 - 01/2017
4	Temozolomide (Temodar)FDA LinkGeneric 01/2023 - 01/2017
4	Biomarkers (Surrogate Marker)IBA 12/2022 - 11/2017
4	RNA (Ribonucleic Acid)IBA 12/2022 - 11/2018
4	Immunoglobulins (Immunoglobulin)IBA 01/2020 - 01/2010
4	KIR ReceptorsIBA 12/2016 - 12/2010
4	Nitric Oxide (Nitrogen Monoxide)FDA Link 10/2012 - 06/2006
3	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2023 - 11/2017
3	Complement System Proteins (Complement)IBA 01/2020 - 07/2014
3	GlycolipidsIBA 01/2016 - 01/2010
3	Interleukin-2 Receptors (IL 2 Receptor)IBA 12/2011 - 03/2006
3	DNA (Deoxyribonucleic Acid)IBA 11/2011 - 09/2002
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2007 - 01/2006
2	CollagenIBA 03/2024 - 11/2023
2	Flavin-Adenine Dinucleotide (FAD)IBA 01/2023 - 01/2021
2	temsirolimus FDA Link 01/2023 - 01/2017
2	Fc Receptors (Fc Receptor)IBA 01/2022 - 01/2012
2	Rituximab (Mabthera)FDA Link 12/2019 - 01/2017
2	HLA-Bw4 antigenIBA 12/2019 - 01/2017
2	Therapeutic UsesIBA 01/2019 - 01/2018
2	Interleukin-15 (Interleukin 15)IBA 01/2018 - 01/2016
2	IgG Receptors (Fc gamma RI)IBA 05/2017 - 01/2016
2	LipidsIBA 11/2013 - 09/2002
2	FenretinideIBA 11/2013 - 11/2011
2	Interferon-gamma (Interferon, gamma)IBA 10/2012 - 01/2004
2	LipopolysaccharidesIBA 10/2012 - 06/2006
2	tucotuzumab celmoleukinIBA 12/2011 - 08/2009
2	ResveratrolIBA 11/2011 - 05/2011
2	Dopamine (Intropin)FDA LinkGeneric 11/2010 - 03/2006
2	Transaminases (Aminotransferases)IBA 11/2010 - 01/2009
1	Doxorubicin (Adriamycin)FDA LinkGeneric 03/2024
1	liposomal doxorubicin (Doxil)FDA Link 03/2024
1	salicylhydroxamic acid (SHAM)IBA 03/2024
1	Chimeric Antigen ReceptorsIBA 12/2023
1	Immunologic Factors (Immunomodulators)IBA 01/2023
1	Oncogene Proteins (Oncogene Protein)IBA 12/2022
1	pyrrolo(2,1-c)(1,4)benzodiazepineIBA 12/2022
1	Adenosine Triphosphate (ATP)IBA 12/2022
1	Immunoconjugates (Immunoconjugate)IBA 12/2022
1	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 12/2022
1	CalreticulinIBA 12/2022
1	GlypicansIBA 12/2022
1	HydrogelsIBA 01/2022
1	AlginatesIBA 01/2022
1	Programmed Cell Death 1 ReceptorIBA 01/2022
1	Messenger RNA (mRNA)IBA 01/2022
1	carboxyaminoimidazole ribotide (CAIR)IBA 01/2022

Therapy/Procedure

60	Immunotherapy 04/2024 - 09/2002
50	Therapeutics 04/2024 - 01/2004
14	Radiotherapy 04/2024 - 01/2012
8	Drug Therapy (Chemotherapy) 11/2017 - 06/2009
5	Ligation 08/2012 - 05/2005
4	Injections 01/2023 - 01/2010
2	Induction Chemotherapy 01/2022 - 11/2019
2	Precision Medicine 01/2021 - 01/2019
2	Intraperitoneal Injections 01/2013 - 05/2005
2	Stem Cell Transplantation 01/2012 - 09/2010
1	Neoadjuvant Therapy 01/2022